Research Overview
Fluorescence
Fluorescence is a kind of luminescence----that is, light that is emitted by cold objects----that occurs when a molecule absorbs a light particle, or photon, which triggers the emission of another photon that has a longer wavelength. Fluorescent molecules have numerous applications, especially in biology and medicine, because they can be used to track or detect very specific molecules that are often present in very low amounts.
Plasmons
Plasmons are a physical phenomenon in which the electrons of a metal oscillate (vibrate) in a coherent way, so that they behave like a vibrating particle. These particle-like vibrations can be used for a number of applications Examples include precise measurements of binding or interactions between biological molecules, or to dramatically increase the sensitivity of a fluorescent signal.
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Research Description
Research Area: Flourescence
Research Specialties: radiative decay engineering, fluorescence sensing
Research in the Institute of Fluorescence is concerned with the development of new leading-edge and existing fluorescence and plasmonic based phenomenon for resolving clinically, biologically and industrially important questions, as well as addressing areas of immense national and international importance. These include the development of clinical devices for health care safeguard and continuous monitoring, the development of technologies to facilitate the early and rapid detection of bio-warfare agents; as well as developing fundamental scientific principles, which are themselves likely to find a global impact and use.
Under the leadership of Dr Chris D. Geddes, Professor and Director of the Institute of Fluorescence, the research group has earned a well-deserved international reputation for its advances in Fluorescence Spectroscopy. Approaches and concepts developed by the group are well-recognized and used in laboratories around the world.
The groups origins in fluorescence spectroscopy and clinical sensing can be traced back to the collaborative efforts with Peter Douglas (UK), himself a student of Nobel Laureate Lord Porter and with Joseph R. Lakowicz, a pioneer in fluorescence spectroscopy and author of the widely used text "Principles of Fluorescence Spectroscopy".
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Representative Publications
"Plasmon light scattering in Biology and Medicine: New sensing approaches, visions and perspectives"
Kadir Aslan, Joseph R. Lakowicz and Chris D. Geddes
Current Opinions in Chemical Biology, 9, 538-544, 2005.
"Angular-Ratiometric Plasmon-Resonance based Light Scattering for Bioaffinity Sensing" Kadir Aslan, Patrick Holley, Lydia Davies, Joseph R. Lakowicz and Chris D. Geddes
Journal of American Chemical Society, 127(34), 12115-12121, 2005.
"Enhanced-fluorescence cyanide detection at physiologically lethal levels: Reduced ICT based signal transduction"
Ramachandram Badugu, Joseph R. Lakowicz and Chris D. Geddes
Journal of American Chemical Society, 127(10), 3635-3641, 2005.
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