Research Overview
Plasmons
In metals, electrons move more freely than in other solids. They sometimes behave like vibrating or oscillating particles, at frequencies similar to those of light, in which case they are referred to as plasmons.
Fluorescent Tags and Detectors
Fluorescent dyes are molecules that absorb light and then emit it at a longer wavelength. The practical effect that we can observe----and that can be detected by various instruments----is that the molecules glow brightly, with a characteristic color.
Fluorescence is quite useful in biotechnology, because they can be used as highly specific tags or probes for...
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Research Description
Research Area: Fluorescence
Research Specialties: fluorescence spectroscopy, plasmons, biosensing
My research focuses on the development and applications of plasmonic / fluorescence-based biosensors using noble metallic nanoparticles. In this regard, we have developed a new approach to glucose sensing based on the reversible aggregation of gold nanoparticles (due to specific dextran / Concanavalin A / glucose interactions) and their respective change in plasmon absorption (and scattering) upon glucose addition. This method proves to offer an across-the-board technology for glucose sensing in different physiological fluids due to its tunable glucose sensing range, where glucose can vary significantly from tears to blood, and its optical compatibility (absorbance above 600 nm).
We have also shown that a fluorescence-based detection scheme for small molecules can be realized using ligand-functionalized gold nanoparticles. The transduction scheme is based on the strong quenching of the...
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Representative Publications
Aslan, K.; Huang, J.; Wilson, G.W.; Geddes*, C.D.Metal-Enhanced Fluorescence-Based RNA Sensing, J. Am. Chem. Soc. (2006), 128(13), 4206-4207.
Aslan, K.; Geddes*, C.D. Microwave-Accelerated Metal-Enhanced Fluorescence (MAMEF): Application to Fast and Sensitive Clinical Assays, J. of Fluorescence (2006), 16(1), 3-8.
Aslan, K.; Geddes*, C.D. Microwave Accelerated and Metal EnhancedFluorescence Myoglobin Detection on Silvered Surfaces: Potential Application to Myocardial Infarction Diagnosis, Plasmonics (2006), 1(1), 53-59.
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