Research OverviewTranslational Control Genetic information is expressed when sequences of DNA are transcribed, ultimately generating, through a number of steps, messenger RNA which is then translated into proteins. Each gene defines one or more amino acid sequences that represent protein chains. The process of translation is controlled throughout the process, including stages known as initiation, elongation, and release. These events involve complex interactions between complexes of proteins and nucleic acids, and since each of these molecules is itself a gene product, translation is ultimately under genetic control... Complete Information... | Research Description Research Area: Molecular Biology of Translational Control Research Specialties: Translational control of gene expression, regulation of gene activity during early development, host defense against virus infection and viral countermeasures, role of protein synthesis in lactation. Research interests - function/evolution of eIF4E related proteins
- function of eIF4E family members in zebrafish development
- role of an interferon-induced protein kinase, PKR, in the molecular pathogenesis of fish viruses
- translational mechanisms governing milk protein production in mammary gland
Until recently, it was believed, through extrapolation from genetic studies in the yeast, that eIF4E was encoded by a single gene in higher eukaryotes. However, recently, through the analysis of whole genome sequences and ESTs, it has become apparent that genes producing many different eIF4E related proteins exist... Complete Information... |
Representative PublicationsJoshi, B, Cameron, A., & Jagus, R. 2004. Characterization of mammalian eIF4E family members. Eur. J. Biochem., 271, 2189-2203 [ABSTRACT]. Robalino, J., Joshi, B., Fahrenkrug, S. C., Jagus, R. 2004. Two zebrafish eIF4E family members are functionally divergent and are differentially expressed. J. Biol. Chem., 279, 10532-10541 [ABSTRACT]. Garner, J. N., Joshi, B, and Jagus, R. 2003. Characterization of rainbow trout and zebrafish eukaryotic initiation factor 2alpha and its response to endoplasmic reticulum stress and IPNV infection. Comp. Dev. Immunol. 27, 217-231 [ABSTRACT]. Complete Listing... |
