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Positions:
Director and Professor*, CBR
Education
Ph.D., 1984, The University of Michigan
Email: payne@umbi.umd.edu
Voice: (301) 405-8389
Mailing info
CBR Faculty Directory
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Research Overview
Biofabrication
Biology enlists a range of materials and mechanisms for construction at the nanoscale. Through extensive collaborations, we are studying and applying these "biofabrication" approaches for technological purposes. In particular, our lab focuses on "biofabricating" with stimuli-responsive biological polymers (especially polysaccharides) and enzymes (especially tyrosinase and transglutaminase). One goal of our work is to create the means for interfacing biology with electronics so devices can better; diagnose disease at the point of care, detect pathogens at the market, and discover drugs in the lab. Another broad goal of biofabrication is to provide biocompatible approaches for: personalized therapy, regenerative medicine, and less-invasive surgery.
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Research Description
Research Area: Nanobiotechnology
Research Specialties: Biofabrication, Chitosan, Tyrosinase, Transglutaminase, Stimuli-responsive Polymers, Electrodeposition, Soft Tissue Adhesive, Biomimetic Materials, Renewable Resources
BIOFABRICATION: Construction Using Biological Materials and Mechanisms
I. BUILDING THE BIO-DEVICE INTERFACE
The last century witnessed spectacular advances in both microelectronics and biotechnology yet there was little synergy between the two. A challenge to their integration is that biological and electronic systems are constructed using divergent fabrication paradigms. Biology fabricates bottom-up with labile components while microelectronic devices are fabricated top-down using methods that are "bio-incompatible". Biofabrication - the use of biological materials and mechanisms for construction - offers the opportunity to span these fabrication paradigms by providing convergent approaches for building the bio-device interface.
Complete Information...
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Additional Info
* Joint Appointment: Professor, Department of Chemical and Biochemical Engineering, University of Maryland, Baltimore County
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Representative Publications
Electroaddressing
Shi, X.-W., X. Yang, K.J. Gaskell, Y. Liu, E. Kobatake, W.E. Bentley, and G.F. Payne. 2009. Reagentless Protein Assembly Triggered By Localized Electrical Signals. Advanced Materials, 21: 984-988.
Meyer, W.L., Y. Liu, X.-W. Shi, X. Yang, W.E. Bentley, and G.F. Payne. 2009. Chitosan-coated Wires: Conferring Electrical Properties to Chitosan Fibers. Biomacromolecules, 10: 858-864.
Shi, X.-W., C.-Y. Tsao, X. Yang, Y. Liu, P. Dykstra, G.W. Rubloff, R. Ghodssi, W.E. Bentley, G.F. Payne. 2009. Electroaddressing of Cell Populations by Co-Deposition with Calcium Alginate Hydrogels. Advanced Functional Materials. 19: 2074-2080.
Complete Listing...
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