The tremendous quantity of sequence data coupled with advances in high-throughput technologies provides an unprecedented opportunity to investigate complex biological systems (organelles, cells, tissues, and organisms) on a global scale. The analysis of systems can reveal emergent properties, such as robustness, that cannot be identified by examining the individual constituents in isolation. Experimental approaches include genome- wide transcriptional profiling to measure gene expression, mass spectrometry of biomolecular complexes to identify protein components and modifications, and chemical screening to analyze post- translational modifications that regulate protein function. The ultimate goal is to integrate the various types of data and generate a model the accurately describes the behavior of the biological system in question.

Faculty:

Dr. Shuwei Li

Dr. Harold Smith

Dr. Illarion Turko