Dr. Osnat Herzberg Representative Publications

For a full PubMed publication list click here.

Chao KL, Muthukumar L, Herzberg O. Structure of Human Hyaluronidase-1, a Hyaluronan Hydrolyzing Enzyme Involved in Tumor Growth and Angiogenesis. Biochemistry, 46, 6911-6920 (2007)

Galkin A, Kulakova L, Melamud E, Li L, Wu C, Mariano P, Dunaway-Mariano D, Nash TE, Herzberg O. Characterization, Kinetics and Crystal Structures of Fructose-1,6-bisphosphate Aldolase from the Human Parasite, Giardia lamblia. J Biol Chem 282, 4859-4867 (2006)

Chen CCH, Han Y, Niu W, Howard A, Quinn JP, Dunaway-Mariano D, Herzberg O. Structure and Kinetics of Phosphonopyruvate Hydrolase from Voriovorax sp. Pal2 New Insight Into the Divergence of Catalysis Within the PEP Mutase/Isocitrate Lyase Superfamily. Biochemistry 45, 11491-11504 (2006)

Teplyakov A, Lim K, Zhu P-P, Kapadia G, Chen CCH, Schwartz J, Howard A, Reddy PT, Peterkofsky A, Herzberg O. Signaling sugar translocation: Structure of phosphorylated Enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system. Proc. Natl. Acad. Sci. USA 103, 16218-16223 (2006)

Teplyakov, A., Liu, S., Lu, Z., Howard, A., Dunaway-Mariano, D., Herzberg, O. Crystal Structure of the Petal Death Protein from Carnation Flower. Biochemistry 44, 16377-16384 (2005)

Galkin, A., Lu, X, Dunaway-Mariano D., Herzberg, O. Crystal structures representing the Michaelis complex and the thiouronium reaction intermediate of Pseudomonas aeruginosa arginine deiminase. J Biol Chem 280, 34080-34087 (2005)

Lehmann C., Pullalarevu S, Krajewski W., Willis M.A., Galkin A., Howard A., Herzberg, O. Structure of HI0073 from Haemophilus influenzae, the nucleotide-binding domain of a two-protein nucleotidyl transferase. Proteins: Struct. Func. & Bioinformatics 60, 807-811 (2005)

Willis M.A., Song F., Zhuang Z., Krajewski W., Chalamasetty V.R., Reddy P., Howard A., Dunaway-Mariano D., Herzberg, O. Structure of YciI from Haemophilus influenzae (HI0828) reveals a ferredoxin-like ?/?-fold with a histidine/aspartate centered catalytic site. Proteins: Struct. Func. & Bioinformatics 59, 648-652 (2005)

Liu S., Lu Z., Han Y., Melamud M., Dunaway-Mariano D., & Herzberg O. Crystal Structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution. Biochemistry 44, 2949-2962 (2005)

Lim K, Doseeva V, Sarikaya E, Pullalarevu S, Krajewski W, Galkin A, Howard A, & Herzberg O. Crystal structure of the YgfY from Escherichia coli, a protein that may be involved in transcriptional regulation. Proteins: Struct. Func. & Bioinformatics, 58, 759-763 (2005)

Galkin A, Sarikaya E., Lehmann C., Howard A., & Herzberg O. X-ray Structure of HI0817 from Haemophilus influenzae: Protein of Unknown Function with a Novel Fold. Proteins: Struct. Func. & Bioinformatics, 57, 874-877 (2004)

Liu S., Lu Z., Han Y., Jia Y., Howard A., Dunaway-Mariano D., & Herzberg O. Conformational Flexibility of PEP Mutase. Biochemistry 43, 4447-4453 (2004)

Lim K., Sarikaya E., Galkin A., Krajewski W., Pullalarevu S., Shin J-H, Kelman Z., Howard A., & Herzberg O. Novel Structure and Nucleotide Binding Properties of HI1480 from Haemophilus influenzae: A Protein with No Known Sequence Homologues. Proteins: Struct. Func. & Genet, 56, 564-71 (2004)

Lehmann C., Doseeva V., Pullalarevu S., Krajewski W., Howard A., & Herzberg O. YbdK is a carboxylate-amine ligase with a y-glutamyl:cysteine ligase activity: Crystal Structure and enzymatic assays. Proteins: Struct. Func. & Genet, 56, 376-83 (2004)

Galkin A, Kulakova L, Sarikaya E, Lim K, Howard A, Herzberg O., Structural insight into arginine degradation by arginine deiminase, an antibacterial and parasite drug target, J Biol Chem. 279 14001-14008 (2004)

Lim K., Tempczyk A., Bonander N., Toedt J., Howard A., Eisenstein, E., and Herzberg, O., A catalytic mechanism for ?-Tyr-tRNA^Tyr deacylase based on the crystal structure of Haemophilus influenzae HI0670, J. Biol. Chem., 278, 13496-13502 (2003)

Lim, K, Tempczyk A., Parsons, J.F., Bonander N., Toedt J, Kelman Z., Howard A., Eisenstein, E., & Herzberg, O., Crystal structure of YbaB from Haemophilus influenzae (HI0442), a protein of unknown function co-expressed with the recombinational DNA repair protein RecR, Proteins: Struct. Func. & Genet, 50, 375-379 (2002)

Lim, K., Zhang, H., Tempczyk, A., Bonander, N., Toedt, T., Howard, A., Eisenstein, E., & Herzberg, O., Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): A cofactor bound at a site formed by a knot, Proteins: Struct. Func. & Genet, 51, 56-57 (2003)

Willis, M.A., Krajewski, W., Chalamasetty, V.R., Reddy, P., Howard, A., & Herzberg, O., Structure of HI1333 (YhbY), a Putative RNA-binding Protein from Haemophilus influenzae, Proteins: Struct. Func. & Genet. 49, 423-426 (2002)

Lehmann, C., Lim K., Chalamasetty, V.R, Krajewski W., Melamud, E., Galkin A., Howard, A., Kelman, Z., Reddy, P., Murzin, A. & Herzberg, O., The HI0073/HI0074 protein pair from Haemophilus influenzae is a member of a new nucleotidyltransferase family: Structure, sequence analyses, and solution studies, Proteins: Struct. Func. & Genet. 50, 249-260 (2003)

S. Liu, Z. Lu, Y. Jia, D. Dunaway-Mariano, & O. Herzberg, Dissociative Phosphoryl Transfer in PEP Mutase Catalysis: Structure of the Enzyme/Sulfopyruvate Complex and Kinetic Properties of Mutants, Biochemistry 41, 10270-10276 (2002)

C. Lehmann, K. Lim, J. Toedt, W. Krajewski, A. Howard, E. Eisenstein & O. Herzberg, Structure 2C-Methyl-D-Erythrol-2,4-Cyclodiphosphate Synthase from Haemophilus influenzae: Activation by Conformational Transition, Proteins: Struct. Func. & Genet, 49, 135-138 (2002)

C. C. H. Chen, H. Zhang, A. D. Kim, A. Howard, G. Sheldrick, D. Mariano-Dunnaway & O. Herzberg, The Degradation Pathway of the Phosphonate Ciliatine: Crystal Structure of 2-Aminoethylphosphonate Transaminase, Biochemistry 41, 13162-13169 (2002)

Parsons, J.F., Lim, K. Tempczyk, A., Eisenstein, E. & Herzberg, O., From Structure to Function: YrbI from Haemophilus influenzae (HI1679) is a Phosphatase, Proteins: Struct. Func. & Genet. 46, 394-404 (2002)

Herzberg, O., Chen, C.C.H., Liu, S., Tempczyk, A., Howard, A., Wei, M., Ye, D., & Dunaway-Mariano, D., The Pyruvate Site of Pyruvate Phosphate Dikinase: Crystal Structure of the Enzyme/Phosphonopyruvate Complex, and Mutant Analysis, Biochemistry 41, 780-787 (2002)

Lim, K., Zhang, H., Tempczyk A., Bonander, N, Toedt, J., Howard, A., Eisenstein, E. & Herzberg,O., Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine, Proteins: Struct. Func. & Genet. 45, 397-407 (2001)

Zhang, H., Huang, K., Li, Z., Banerjee, S., Fischer, K.E., Grishin, N.V., Eisenstein, E. & Herzberg, O., Chen, C.C.H., Herzberg, O., Structures of the Acyl-Enzyme Complexes of the Staphylococcus aureus ?-Lactamase Mutant Glu166Asp:Asn170Gln with Benzylpenicillin and Cephaloridine, Biochemistry 40, 2351-2358 (2001)

Zhang, H., Huang, K., Li, Z., Banerjee, S., Fischer, K.E., Grishin, N.V., Eisenstein, E. & Herzberg, O., Crystal structure of YbaK from Haemophilus influenzae (HI1434) at 1.8 resolution: functional implications, Proteins: Struct. Func. & Genet. 40, 86-97 (2000)

Chen, C.C.H. & Herzberg, O., Relocation of the Catalytic Carboxylate Group in Class A ?-Lactamase: The Structure and Function of the Mutant Enzyme Glu166 Gln:Asn170Asp, Protein Engineering 12, 573-579 (1999)

Huang, K., Li, Z., Jia, Y., Dunaway-Mariano, D. & Herzberg, O., Helix swapping between two ?/? barrels: Crystal structure of, phosphoenolpyruvate mutase with bound Mg²⁺-oxalate, Structure 7, 539-548 (1999)

Banerjee, S., Pieper, U., Kapadia, G., Pannel, L.K. & Herzberg, O., The role of the ?-loop in the activity, substrate specificity, and structure of class A B-lactamase, Biochemistry 37, 3286-3296 (1998)

Zawadzke, L.E., Chen, C.C.H., Banerjee, S., Li, Z., Wsch, S., Kapadia, K., Moult, J. & Herzberg, O., Elimination of the hydrolytic water molecule in a class A ?-lactamase mutant: Crystal structure and kinetics, Biochemistry 35, 16475-16482 (1996)

Concha, N.O., Rasmussen, B.A., Bush, K. & Herzberg, O., Crystal structure of the wide-spectrum binuclear zinc ?-lactamase from Bacteroides fragilis, Structure 4, 823-836 (1996)

O. Herzberg, C.C.H. Chen, G. Kapadia, M. McGuire, L.J. Carroll, S.J. Noh & D. Dunaway-Mariano, Swiveling-domain mechanism for enzymatic phosphotransfer between remote reaction sites, Proc. Natl. Acad. Sci. USA, 93, 2652-2657 (1996)

L.E. Zawadzke, T.J. Smith & O. Herzberg, An engineered Staphylococcus aureus PC1 ?-lactamase that hydrolyses third generation cephalosporins, Protein Engineering, 8, 1275-1285 (1995)

D-I. Liao, G. Kapadia, H. Ahmed, G.R. Vasta & O. Herzberg, Structure of S-lectin, a developmentally regulated vertebrate b-galactoside binding protein, Proc. Natl. Acad. Sci. USA. 91, 1428-1432 (1994)

C.C.H. Chen, J. Rahil, R.F.Pratt & O. Herzberg, Structure of a phosphonate-inhibited ?-lactamase: An analog of the tetrahedral transition state/intermediate of ?-lactam hydrolysis, J. Mol. Biol., 234, 165-178 (1993)

O. Herzberg, An atomic model for protein-protein phosphoryl group transfer, J. Biol. Chem. 267, 24819-24823 (1992)

O. Herzberg, P. Reddy, M.H.Jr. Saier, J. Reizer & G. Kapadia Structure of the histidine-containing phosphocarrier protein HPr from Bacillus subtilis at 2.0 resolution, Proc. Natl. Acad. Sci. USA. 89, 2499-2405 (1992)

C.C.H. Chen and O. Herzberg Inactivation of ?-lactamase by clavulanate: trapped intermediates in cryo-cryocrystallographic studies, J. Mol. Biol. 224, 1103-1113 (1992)

D-I. Liao, G. Kapadia, P. Reddy, M.H.Jr. Saier, J. Reizer & O. Herzberg, Structure of the IIA domain of the glucose permease of Bacillus subtilis at 2.2 resolution, Biochemistry 30, 9583-9594 (1991)

O. Herzberg & J. Moult, Analysis of the Steric Strain in the Polypeptide Backbone of Protein molecules, Proteins: Struc. Funct. & Genet. 11, 223-229 (1991)

O. Herzberg, Refined Crystal Structure of B-Lactamase from Staphylococcus aureus PC1 at 2.0 resolution, J. Mol. Biol. 217, 701-719 (1991)

K. Fujimori, M. Sorenson, O. Herzberg, J. Moult & F.C. Reinach, Probing the Ca²⁺-Induced Conformational Transition of Troponin C with Site-Directed Mutants, Nature, 344, 182-184 (1990)

O. Herzberg and M.N.G. James, Refined Crystal Structure of Troponin C from Turkey Skeletal Muscle at 2.0 Resolution, J. Mol. Biol., 203, 761-779 (1988)

O. Herzberg and J. Moult, Molecular Basis for Bacterial Resistance to ?-Lactam Antibiotics: Crystal Structure of ?-Lactamase from Staphylococcus Aureus PC1 at 2.5 resolution, Science 236, 694-701 (1987)

O. Herzberg, J. Moult and M.N.G. James, A Model for the Ca²⁺ Induced Conformational Transition of Troponin-C: a Trigger for Muscle Contraction, J. Biol. Chem., 261, 2638-2644 (1986)

O. Herzberg and M.N.G. James, Structure of the Calcium Regulatory Muscle Protein Troponin-C at 2.8 Resolution Nature 313, 653-659 (1985)